Introducing AmplifyAssist

Support throughout your treatment journey

AmplifyAssist™ is a support program from Zevra Therapeutics for people prescribed OLPRUVA, and for their caregivers and advocates. Whether you’re trying to access therapy for the first time or you’ve been on it for months, AmplifyAssist has your back.

Getting OLPRUVA: How AmplifyAssist can help

Managing UCDs is complex, and we believe getting your medication shouldn’t add to the burden. That’s why our support starts right after your doctor submits your Enrollment Form. Once it’s received, your dedicated AmplifyAssist team sets the support process in motion, ready to:

Help with timely access to treatment

Make sure OLPRUVA treatment is clearly understood

Provide support at every step

Services include but are not limited to:

Commercial copay assistance program for eligible patients*

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Coordination of efforts between your insurance company and healthcare providers to secure product coverage

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Letter of Medical Necessity (LMN) templates sent to your healthcare providers’ offices when requested

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Help with understanding your insurance coverage and out-of-pocket cost for therapy

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Delivery of product to your home or address of choice

Supply of product free of charge to eligible patients*

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Product and disease-state information, including tips and tools for product management

Monthly refill reminder calls and delivery scheduling to avoid lapses in therapy

Assistance with identifying alternative funding resources for patients who do not qualify for the commercial copay assistance program

The AmplifyAssist team does not offer medical advice or replace discussions with your healthcare provider(s).

*Eligibility criteria and maximum limits apply. Contact your AmplifyAssist team for details.

A partnership focused on you

You can access the AmplifyAssist Team Monday-Friday, 8 am-6 pm CT, at 1-888-668-4198.

To learn more about AmplifyAssist, our patient support program for OLPRUVA, click here.

Zevra Therapeutics has partnered with a specialty pharmacy to optimize your access and support experience during OLPRUVA treatment. The AmplifyAssist team offers personalized education and support, including financial support and assistance for eligible patients. The AmplifyAssist team does not offer medical advice or replace discussions with a healthcare provider.

Not actual patients

Financial assistance may be available for eligible patients. Let’s talk.

Zevra Therapeutics is committed to helping make OLPRUVA affordable. Your AmplifyAssist team will explain your financial support options to help you or your loved one get treatment as prescribed.

You can access the AmplifyAssist Team Monday-Friday, 8 am-6 pm CT, at 1-888-668-4198.

Visit the AmplifyAssist website

This summary does not include all information about OLPRUVA and is not meant to take the place of discussions with your healthcare provider about your or your child’s treatment. Please read this important information carefully and discuss any questions about OLPRUVA with your healthcare provider.

What is OLPRUVA?

OLPRUVA is a prescription medicine used along with certain therapy, including changes in diet, for the long-term management of adults and children 1 year old or older, weighing 15 pounds (7 kg) or greater, with urea cycle disorders (UCDs), involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC) or argininosuccinic acid synthetase (AS).
Episodes of rapid increase of ammonia in the blood (acute hyperammonemia) may happen in patients during treatment with OLPRUVA. OLPRUVA is not for the treatment of acute hyperammonemia, which can be life-threatening and requires emergency medical treatment.
OLPRUVA is not approved in children younger than 1 year of age due to the amount of water needed to take OLPRUVA.

Before taking OLPRUVA, tell your or your child’s healthcare provider about all your medical conditions, including if you:

have heart problems
have kidney or liver problems
are pregnant or plan to become pregnant. It is not known if OLPRUVA will harm your unborn baby. If you become pregnant during treatment with OLPRUVA, call your doctor to report the pregnancy.
are breastfeeding or plan to breastfeed. It is not known if OLPRUVA passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take OLPRUVA.

Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Certain medicines may increase the level of ammonia in your blood or cause serious side effects when taken during treatment with OLPRUVA. Especially tell your healthcare provider if you or your child take:

corticosteroids
valproic acid
haloperidol
probenecid

Know the medicines you take. Keep a list of them to show your or your child’s healthcare provider and pharmacist when you get a new medicine. Keep OLPRUVA and all medicines out of the reach of children.

How should I or my child take OLPRUVA?

Read the detailed Instructions for Use that comes with OLPRUVA for information about the right way to prepare and take a dose of OLPRUVA.

Take OLPRUVA exactly as prescribed by your healthcare provider.
Your healthcare provider may change your dose if needed. Do not change your dose unless your healthcare provider tells you to.
Your healthcare provider will prescribe OLPRUVA based on your or your child’s weight.
Take your OLPRUVA dose with food.
If you miss a dose of OLPRUVA, take it as soon as possible that same day.
Do not give or take OLPRUVA through a nasogastric tube.
If you take too much OLPRUVA, call your healthcare provider or go to the nearest hospital emergency room right away.

What are the possible side effects of OLPRUVA?

OLPRUVA can cause serious side effects, including:

Nervous system problems (neurotoxicity). Call your healthcare provider right away if you or your child get any of the following symptoms during treatment with OLPRUVA:
- sleepiness
- nausea
- tiredness
- headache
- lightheadedness
- confusion
- vomiting
Low potassium levels in your blood (hypokalemia). Your healthcare provider will monitor your blood potassium levels during treatment with OLPRUVA and treat if needed.
Conditions related to swelling (edema). OLPRUVA contains salt (sodium), which can cause swelling from salt and water retention. Your healthcare provider will decide if OLPRUVA is right for you if you have certain medical conditions that cause edema, such as heart failure, liver problems or kidney problems.

The most common side effects of OLPRUVA include:

absent or irregular menstrual periods
body odor
decreased appetite
bad taste or avoiding foods that you ate prior to getting sick (taste aversion)

Your healthcare provider may do certain blood tests to check you or your child for side effects during treatment with OLPRUVA.

These are not all of the possible side effects of OLPRUVA. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

For additional Important Safety Information see full Prescribing Information and Patient Information, including Instructions for Use, and discuss with your doctor.

Summary of Important Safety Information for OLPRUVA

OLPRUVA [ol proo vah] (sodium phenylbutyrate) for oral suspension

The information provided in this website is intended for US residents.

OLPRUVA is a registered trademark of Acer Therapeutics, Inc., a wholly owned subsidiary of Zevra Therapeutics, Inc. AMPLIFYASSIST is a trademark of Zevra Therapeutics, Inc. © 2025 Zevra Therapeutics, Inc. All rights reserved. PRC-OLP-25-030 12/25

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Getting your medication with support from AmplifyAssist™